BACTERICIDAL ACTION OF PD127,391, AN ENHANCED SPECTRUM QUINOLONE

被引：7

作者：

LEWIN, CS

AMYES, SGB

机构：

来源：

JOURNAL OF MEDICAL MICROBIOLOGY | 1990年 / 33卷 / 01期

关键词：

D O I：

10.1099/00222615-33-1-67

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 4-quinolone PD127,391 displays a biphasic effect on Escherichia coli, Staphylococcus aureus and S. epidermidis in nutrient broth. It is as active as ciprofloxacin in terms of its optimum bactericidal concentration against E. coli. However, against staphylococci it is six times as active as ciprofloxacin or any other 4-quinolone previously investigated. Although protein and RNA synthesis are not required for bactericidal activity, cell division is essential.

引用

页码：67 / 70

页数：4

共 14 条

[11]

Smith J. R., 1984, Proceedings of the 1984 International Conference on Parallel Processing (Cat. No. 84CH2045-3), P299

[12] TRIMETHOPRIM RESISTANCE DETERMINANTS ENCODING A DIHYDROFOLATE-REDUCTASE IN CLINICAL ISOLATES OF STAPHYLOCOCCUS-AUREUS AND COAGULASE-NEGATIVE STAPHYLOCOCCI [J].