EFFECT OF CORTICOSTEROID TREATMENT ON INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR SECRETION BY MONOCYTES FROM SUBJECTS WITH ASTHMA

被引：39

作者：

VECCHIARELLI, A ^{[1
]}

SIRACUSA, A ^{[1
]}

CENCI, E ^{[1
]}

PULITI, M ^{[1
]}

ABBRITTI, G ^{[1
]}

机构：

[1] UNIV PERUGIA,INST OCCUPAT MED,I-06100 PERUGIA,ITALY

来源：

CLINICAL AND EXPERIMENTAL ALLERGY | 1992年 / 22卷 / 03期

关键词：

D O I：

10.1111/j.1365-2222.1992.tb03097.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Peripheral blood monocytes (PBM) may be activated in asthmatic patients, a condition usually reverted by corticosteroid (CS) treatment. In the present research we have evaluated the spontaneous or lipopolysaccharide (LPS)-induced production of interleukin 1 (IL-1) and tumour necrosis factor (TNF) by PBM obtained from 14 asthmatic subjects during an asthmatic attack and after 1 week of CS treatment. The control group included 20 healthy volunteers. PBM obtained during severe asthma showed a pattern of IL-1 and TNF secretion similar to that of normal subjects. After CS treatment, IL-1 levels did not change significantly in comparison to baseline values, while LPS-induced TNF production was apparently related to the degree of airway obstruction after CS treatment. In fact, TNF production by PBM from CS-responsive subjects was significantly decreased in comparison to the levels determined before CS treatment, while PBM from CS-resistant subjects produced the same cytokine levels regardless of CS treatment. The present study suggests that the determination of LPS-induced TNF secretion by PBM could be used to confirm the effectiveness of CS treatment in asthma.

引用

页码：365 / 370

页数：6

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