Genes encoding the beta 1 subunit of voltage-dependent Na+ channel in rat, mouse and human contain conserved introns

被引：17

作者：

DibHajj, SD

Waxman, SG

机构：

[1] YALE UNIV, SCH MED, DEPT NEUROL, LCI 707, NEW HAVEN, CT 06510 USA

[2] VET ADM MED CTR, NEUROSCI RES CTR, W HAVEN, CT 06516 USA

来源：

FEBS LETTERS | 1995年 / 377卷 / 03期

关键词：

voltage-gated sodium channel; beta; 1; subunit; gene structure; intron retention;

D O I：

10.1016/0014-5793(95)01400-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We provide evidence in this study that the 86-bp insert in the beta(1.2) mRNA isoform of the voltage gated sodium channel is an intron, Transcripts still retaining this intron were detected in all tissues where the pi gene expression was investigated, We also show that the exon/intron boundaries of the last two introns are conserved among rat, mouse and human beta 1 gene, Unlike the highly conserved cDNAs, introns in only the rat and mouse genes are highly related, The last intron is very short (86-90 bp) and is located in the 3' untranslated sequence, both uncommon properties of mammalian pre-mRNA introns.

引用

页码：485 / 488

页数：4

共 35 条

[1] SPLICING OF EFFECTOR CELL PROTEASE RECEPTOR-1 MESSENGER-RNA IS MODULATED BY AN UNUSUAL RETAINED INTRON [J].