BA2+ CURRENT OSCILLATION EVOKED BY BRADYKININ IN RAS-TRANSFORMED FIBROBLASTS

被引：7

作者：

HIGASHIDA, H ^{[1
]}

HOSHI, N ^{[1
]}

HASHII, M ^{[1
]}

FU, T ^{[1
]}

NODA, M ^{[1
]}

NOZAWA, Y ^{[1
]}

机构：

[1] GIFU UNIV,SCH MED,DEPT BIOCHEM,GIFU 500,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 178卷 / 02期

关键词：

D O I：

10.1016/0006-291X(91)90166-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

By voltage-clamp recording, we show a novel inward current which oscillates after activation with bradykinin or serum in v-Ki-ras-transformed NIH 3T3 cells. The current oscillation was infrequently observed in control NIH 3T3 fibroblasts. The same stimulation evokes Ca2+ oscillations in the ras-transformed cells but not in parental cells (Fu et al., FEBS Lett. 281, 263-266, 1991). The results suggest that the oscillatory currents are generated by influxes of divalent cations to maintain Ca2+ oscillations in ras-transformed NIH 3T3 cells. © 1991.

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页码：713 / 717

页数：5

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