PROTACTIN, A NEW ANTIBIOTIC METABOLITE AND A POSSIBLE PRECURSOR OF THE ACTINOMYCINS

被引：5

作者：

HANADA, M

SUGAWARA, K

NISHIYAMA, Y

KAMEI, H

HATORI, M

KONISHI, M

机构：

[1] Bristol-Myers Squibb Research Institute, Tokyo 153, 2-9-3 Shimo-meguro, Meguro-ku

来源：

JOURNAL OF ANTIBIOTICS | 1992年 / 45卷 / 01期

关键词：

D O I：

10.7164/antibiotics.45.20

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Streptomyces cucumerosporus strain L703-4 (ATCC 53784) produces a new 4-methyl-3-hydroxyanthraniloylpentapeptide lactone for which we have proposed the name protactin, in addition to several actinomycin components. Protactin is rather resistant to air oxidation but it can be converted to a new actinomycin, actinomycin Zp by ferricyanide oxidation. Actinomycin Zp possesses in vitro antibacterial activity and in vivo antitumor activity against P-388 leukemia in mice.

引用

页码：20 / 28

页数：9

共 8 条

[1] IDENTIFICATION OF CIS-5-METHYLPROLINE IN HYDROLYSATES OF ACTINOMYCIN Z5 [J].