MOLECULAR EVOLUTION OF CYCLOOXYGENASE AND LIPOXYGENASE

被引：27

作者：

TOH, H

YOKOYAMA, C

TANABE, T

YOSHIMOTO, T

YAMAMOTO, S

机构：

[1] NATL CARDIOVASC CTR,RES INST,DEPT PHARMACOL,SUITA,OSAKA 565,JAPAN

[2] UNIV TOKUSHIMA,SCH MED,DEPT BIOCHEM,TOKUSHIMA 770,JAPAN

来源：

PROSTAGLANDINS | 1992年 / 44卷 / 04期

关键词：

D O I：

10.1016/0090-6980(92)90004-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four oxygenases of the arachidonic acid cascade (cyclooxygenase, 5-lipoxygenase, 12-lipoxygenase and 15-lipoxygenase) were investigated by the method of computer-assisted sequence comparison. From the calculations, some aspects of evolution and function of these enzymes were revealed. (1) The evolutionary origin of cyclooxygenases was different from that of lipoxygenases. (2) Cyclooxygenase was a distantly related member of a peroxidase family. (3) Enzymes with 12-lipoxygenase activity were created independently twice by gene duplication.

引用

页码：291 / 315

页数：25

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