IS LEAD TOXICOSIS A REFLECTION OF ALTERED FATTY-ACID COMPOSITION OF MEMBRANES

被引：78

作者：

DONALDSON, WE ^{[1
]}

KNOWLES, SO ^{[1
]}

机构：

[1] N CAROLINA STATE UNIV, DEPT TOXICOL, RALEIGH, NC 27695 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY | 1993年 / 104卷 / 03期

关键词：

D O I：

10.1016/0742-8413(93)90003-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The premise of this review is that many of the biological effects of Pb are reflections of tissue peroxidation. 2. Enhanced tissue levels of arachidonic acid in Pb toxicosis appear to be involved in the peroxidative changes. 3. The altered arachidonate metabolism may be related to changes in membrane structure and function. 4. The induction of enhanced glutathione levels in animal tissues by Pb may afford protection from peroxidative damage.

引用

页码：377 / 379

页数：3