SYNTHESIS AND CYTOTOXIC ACTIVITY OF 2-DIALKYLAMINO-ALKYL-1,3-DIHYDROPYRROLO[3,4-C]QUINOLINE-1,3-DIONES AND 6-(2-DIMETHYLAMINOETHYL)-1H-DIBENZ[C,E]AZEPINE-5,7-DIONE

被引：17

作者：

GANJIAN, I

KHORSHIDI, M

LALEZARI, I

机构：

[1] ALBERT EINSTEIN COLL MED,BRONX,NY 10467

[2] MONTEFIORE MED CTR,ORGAN CHEM LAB,BRONX,NY 10467

[3] MONTEFIORE MED CTR,DEPT MED,DIV IMMUNOHEMATOL,BRONX,NY 10467

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1991年 / 28卷 / 05期

关键词：

D O I：

10.1002/jhet.5570280502

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title compounds were synthesized. Cyclodehydration of aromatic 1,2-dicarboxylic acids, in the presence of dicyclohexylcarbodiimide, to the corresponding N-substituted imides is discussed. Compounds 8 and 10 were tested in vitro against K562 and HL-60 cell lines. Compound 10 exhibited moderate cytotoxic activity.

引用

页码：1173 / 1175

页数：3

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