A DECADE OF PROGRESS IN STATISTICAL METHODOLOGY FOR CLINICAL-TRIALS

被引：25

作者：

SIMON, R

机构：

[1] National Cancer Institute Building EPN, Bethesda, Maryland, 20892

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 12期

关键词：

D O I：

10.1002/sim.4780101203

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Clinical trials played a dominant and expanding role in the evaluation of new treatments during the decade of the 1980s. There were major improvements in the quality of clinical trials in many medical fields. There were also important developments in the methodology of designing, monitoring, conducting, analysing, reporting and interpreting clinical trials. This paper attempts to review some of these developments. A comprehensive review is beyond the abilities of any one individual. Consequently, this paper attempts to offer a broad stroke description of this area and to highlight specific topics of importance based on my particular experience. An extensive, but non-comprehensive bibliography is included to provide entry points to the literature of methodologic developments for clinical trials in the 1980s.

引用

页码：1789 / 1817

页数：29

共 229 条

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