INHIBITION OF DIHYDROFOLATE-REDUCTASE - STRUCTURE-ACTIVITY CORRELATIONS OF QUINAZOLINES BASED UPON MOLECULAR SHAPE-ANALYSIS

被引：24

作者：

BATTERSHELL, C ^{[1
]}

MALHOTRA, D ^{[1
]}

HOPFINGER, AJ ^{[1
]}

机构：

[1] CASE WESTERN RESERVE UNIV,CASE INST TECHNOL,DEPT MACROMOLEC SCI,CLEVELAND,OH 44106

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 07期

关键词：

D O I：

10.1021/jm00139a009

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：812 / 818

页数：7

共 18 条

[1]

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[2]

[Anonymous], CONFORMATIONAL PROPE

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[4] SYNTHESIS OF 5-SUBSTITUTED QUINAZOLINES AS POTENTIAL ANTIMALARIAL AGENTS [J].

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[5] DIHYDROFOLATE-REDUCTASE INHIBITION BY 2,4-DIAMINOTRIAZINES - STRUCTURE-ACTIVITY STUDY [J].

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[6] INHIBITION OF DIHYDROFOLATE-REDUCTASE - STRUCTURE-ACTIVITY CORRELATIONS OF QUINAZOLINES [J].

FUKUNAGA, JY ;

HANSCH, C ;

STELLER, EE .

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[7]

Hansch C, 1979, SUBSTITUENT CONSTANT

[8] A GENERAL QSAR FOR DIHYDROFOLATE-REDUCTASE INHIBITION BY 2,4-DIAMINOTRIAZINES BASED UPON MOLECULAR SHAPE-ANALYSIS [J].

HOPFINGER, AJ .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1981, 206 (01) :153-163

[9] A QSAR INVESTIGATION OF DIHYDROFOLATE-REDUCTASE INHIBITION BY BAKER TRIAZINES BASED UPON MOLECULAR SHAPE-ANALYSIS [J].

HOPFINGER, AJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1980, 102 (24) :7196-7206

[10] QUINAZOLINES AS INHIBITORS OF DIHYDROFOLATE-REDUCTASE .2. [J].

HYNES, JB ;

ASHTON, WT ;

BRYANSMITH, D ;

FREISHEIM, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (09) :1023-1025

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