INHIBITION OF DIHYDROFOLATE-REDUCTASE - STRUCTURE-ACTIVITY CORRELATIONS OF QUINAZOLINES

被引：46

作者：

FUKUNAGA, JY ^{[1
]}

HANSCH, C ^{[1
]}

STELLER, EE ^{[1
]}

机构：

[1] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1976年 / 19卷 / 05期

关键词：

D O I：

10.1021/jm00227a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：605 / 611

页数：7

共 11 条

[1] QUINAZOLINES AS INHIBITORS OF DIHYDROFOLATE REDUCTASE .1. [J].

ASHTON, WT ;

WALKER, FC ;

HYNES, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (06) :694-697

[2] SYNTHESIS OF 5-SUBSTITUTED QUINAZOLINES AS POTENTIAL ANTIMALARIAL AGENTS [J].

ASHTON, WT ;

HYNES, JB .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1233-1237

[3] REGRESSIONS BY LEAPS AND BOUNDS [J].

FURNIVAL, GM ;

WILSON, RW .

TECHNOMETRICS, 1974, 16 (04) :499-511

[4] FORMULATION OF DENOVO SUBSTITUENT CONSTANTS IN CORRELATION ANALYSIS - INHIBITION OF DIHYDROFOLATE-REDUCTASE BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-SUBSTITUTED PYRIMIDINES [J].

HANSCH, C ;

SILIPO, C ;

STELLER, EE .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1975, 64 (07) :1186-1191

[5] QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP OF REVERSIBLE DIHYDROFOLATE-REDUCTASE INHIBITORS - DIAMINOTRIAZINES [J].

HANSCH, C ;

SILIPO, C .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (07) :661-667

[6] AROMATIC SUBSTITUENT CONSTANTS FOR STRUCTURE-ACTIVITY CORRELATIONS [J].

HANSCH, C ;

LEO, A ;

UNGER, SH ;

KIM, KH ;

NIKAITANI, D ;

LIEN, EJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (11) :1207-1216

[7] QUINAZOLINES AS INHIBITORS OF DIHYDROFOLATE-REDUCTASE .2. [J].

HYNES, JB ;

ASHTON, WT ;

BRYANSMITH, D ;

FREISHEIM, JH .

JOURNAL OF MEDICINAL CHEMISTRY, 1974, 17 (09) :1023-1025

[8] SYNTHESIS AND EVALUATION OF 6-ARYLACETAMIDO-2,4-DIAMINOQUINAZOLINES AND RELATED COMPOUNDS AS FOLIC-ACID ANTAGONISTS [J].

HYNES, JB ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (03) :263-265

[9] SYNTHESIS OF QUINAZOLINE ANALOGS OF ISOFOLIC ACID [J].

HYNES, JB ;

GARRETT, CM .

JOURNAL OF MEDICINAL CHEMISTRY, 1975, 18 (06) :632-634

[10] CORRELATION ANALYSIS - ITS APPLICATION TO STRUCTURE-ACTIVITY RELATIONSHIP OF TRIAZINES INHIBITING DIHYDROFOLATE-REDUCTASE [J].

SILIPO, C ;

HANSCH, C .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1975, 97 (23) :6849-6861

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