CORRELATION ANALYSIS - ITS APPLICATION TO STRUCTURE-ACTIVITY RELATIONSHIP OF TRIAZINES INHIBITING DIHYDROFOLATE-REDUCTASE

被引:106
作者
SILIPO, C [1 ]
HANSCH, C [1 ]
机构
[1] POMONA COLL,DEPT CHEM,CLAREMONT,CA 91711
关键词
D O I
10.1021/ja00856a042
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:6849 / 6861
页数:13
相关论文
共 58 条
[1]   ACTION OF ANESTHETICS ON EXCITABLE MEMBRANES - A QUANTUM-CHEMICAL ANALYSIS [J].
AGIN, D ;
HERSH, L ;
HOLTZMAN, D .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 53 (05) :952-&
[2]   IRREVERSIBLE ENZYME-INHIBITORS .198. DIAMINODIHYDRO-S-TRIAZINES AND DIAMINOPYRIMIDINES BEARING SUBSTITUTED (UREIDOMETHYL)PHENYL SUBSTITUENTS AS REVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE [J].
ASHTON, WT ;
KIRK, LL ;
BAKER, BR .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (05) :453-456
[4]   IRREVERSIBLE ENZYME INHIBITORS .160. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-L-(PHENYLALKYLPHENYL)-S-TRIAZINES [J].
BAKER, BR ;
JANSON, EE ;
VERMEULEN, NM .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :898-+
[6]   IRREVERSIBLE ENZYME INHIBITORS .159. EFFECT OF SUBSTITUTION ON TRANSPORT AND ISOZYME SPECIFICITY OF P-(4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZIN-L-YL)-O-CHLOROPHENOXYACETAMIDO-BENZENESULFONYL FLUORIDE, AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE [J].
BAKER, BR ;
ASHTON, WT .
JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :894-&
[9]   IRREVERSIBLE ENZYME-INHIBITORS .197. WATER-SOLUBLE REVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE WITH POTENT ANTITUMOR ACTIVITY DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE [J].
BAKER, BR ;
ASHTON, WT .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :209-214
[10]  
BAKER BR, 1968, J MED CHEM, V11, P666, DOI 10.1021/jm00310a007