IRREVERSIBLE ENZYME INHIBITORS .109. CANDIDATE IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE .3.

被引：18

作者：

BAKER, BR

LOURENS, GJ

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 01期

关键词：

D O I：

10.1021/jm00307a005

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：26 / &

共 29 条

[1]

BAKER BERNARD R., 1959, CANCER CHEMOTHERAPY REPTS, V4, P1

[2] IRREVERSIBLE ENZYME INHIBITORS .105. DIFFERENTIAL IRREVERSIBLE INHIBITION OF VERTEBRATE DIHYDROFOLIC REDUCTASES BY DERIVATIVES OF 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINES SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1113-+

[3] FACTORS IN DESIGN OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS [J].

BAKER, BR .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1964, 53 (04) :347-&

[4] ANALOGS OF TETRAHYDROFOLIC ACID .27. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE BY 2-AMINO-4,6-DISUBSTITUTED-5-ALKYLPYRIMIDINES AND 1-ALKYL-4,6-DIAMINO-1,2-DIHYDRO-S-TRIAZINES [J].

BAKER, BR ;

HO, BT ;

SANTI, DV .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1965, 54 (10) :1415-&

[5]

BAKER BR, 1966, J PHARM SCI, V55, P295

[6] IRREVERSIBLE ENZYME INHIBITORS .70. CANDIDATE ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE .4. SUBSTITUTED 1-PHENYL-1,2-DIHYDRO-S-TRIAZINES [J].

BAKER, BR ;

HO, BT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (01) :28-&

[7] ANALOGS OF TETRAHYDROFOLIC ACID .29. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .2. ON MODE OF PHENYL BINDING OF 1-ARYL-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINES [J].

BAKER, BR ;

HO, BT .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :335-&

[8] ANALOGS OF TETRAHYDROFOLOC ACID 34 - HYDROPHOBIC BONDING TO DIHYDROFOLOC REDUCTASE .6. MODE OF PHENYL BINDING OF SOME 6-ARYLPYRIMIDINES [J].

BAKER, BR ;

SHAPIRO, HS .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1966, 55 (03) :308-&

[9] NONCLASSICAL ANTIMETABOLITES .16. BRIDGE PRINCIPLE OF SPECIFICITY WITH ACTIVE SITE-DIRECTED IRREVERSIBLE INHIBITORS .7. DETECTION OF DIFFERENCES IN SPECIFICITY OF ENZYMIC NUCLEOPHILIC SITES BY MALEAMYL GROUP [J].

BAKER, BR ;

ALUMAULA, PI .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1963, 52 (09) :914-&

[10] IRREVERSIBLE ENZYME INHIBITORS .108. 6-(P-CHLOROACETYLANILINOMETHYL)-5-(P-CHLOROPHENYL)-2,4-DIAMINOPYRIMIDINE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE [J].

BAKER, BR ;

HUANG, PC ;

POGOLOTTI, AL .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1134-+

← 1 2 3 →