IRREVERSIBLE ENZYME-INHIBITORS .198. DIAMINODIHYDRO-S-TRIAZINES AND DIAMINOPYRIMIDINES BEARING SUBSTITUTED (UREIDOMETHYL)PHENYL SUBSTITUENTS AS REVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE

被引：6

作者：

ASHTON, WT ^{[1
]}

KIRK, LL ^{[1
]}

BAKER, BR ^{[1
]}

机构：

[1] UNIV CALIF,DEPT CHEM,SANTA BARBARA,CA 93106

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1973年 / 16卷 / 05期

关键词：

D O I：

10.1021/jm00263a006

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：453 / 456

页数：4

共 12 条

[1] IRREVERSIBLE ENZYME INHIBITORS .109. CANDIDATE IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE .3. [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :26-&

[2] IRREVERSIBLE ENZYME INHIBITORS .179. ACTIVE-SITE-DIRECTEC IRREVERSIBLE ENZYME INHIBITORS OF DIHYDROFOLATE REDUCTASE FROM 1-(3-CHLOROPHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE WITH OXYAMIDE BRIDGES TO A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1165-&

[3] IRREVERSIBLE ENZYME-INHIBITORS .197. WATER-SOLUBLE REVERSIBLE INHIBITORS OF DIHYDROFOLATE REDUCTASE WITH POTENT ANTITUMOR ACTIVITY DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE [J].

BAKER, BR ;

ASHTON, WT .

JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (03) :209-214

[4] IRREVERSIBLE ENZYME INHIBITORS .173. CURE OF WALKER-256 ASCITES BY RVERSIBLE AND IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 1-(SUBSTITUTED-PHENYL)-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINE [J].

BAKER, BR ;

VERMEULEN, NM ;

ASHTON, WT ;

RYAN, AJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1970, 13 (06) :1130-+

[5] IRREVERSIBLE ENZYME INHIBITORS .112. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE .2. [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :38-&

[6]

CLARKE HT, 1941, ORGANIC SYNTHESES, V1

[7]

FOLSCH E, 1970, MOL PHARMACOL, V6, P93

[8] A modification of the Gabriel synthesis of amines. [J].

Ing, HR ;

Manske, RHF .

JOURNAL OF THE CHEMICAL SOCIETY, 1926, :2348-2351

[9]

JULIA J, 1962, B SOC CHIM FR, P2247

[10] CHEMICAL AND BIOLOGICAL STUDIES ON 1,2-DIHYDRO-S-TRIAZINES .2. 3-COMPONENT SYNTHESIS [J].

MODEST, EJ .

JOURNAL OF ORGANIC CHEMISTRY, 1956, 21 (01) :1-13

← 1 2 →