IRREVERSIBLE ENZYME INHIBITORS .128. P-(4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZIN-1-YL)PHENYLPROPIONYLSULFANILYL FLUORIDE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE .4. EFFECTS OF SUBSTITUTION ON PROPIONAMIDE BRIDGE ON ISOZYME SPECIFICITY

被引：11

作者：

BAKER, BR

LOURENS, GJ

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1968年 / 11卷 / 04期

关键词：

D O I：

10.1021/jm00310a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

收藏

页码：672 / &

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共 22 条

[1] NON-CLASSICAL ANTIMETABOLITES .6. 4-(IODOACETAMIDO)-SALICYLIC ACID, AN EXO-ALKYLATING IRREVERSIBLE INHIBITOR [J].

BAKER, BR ;

LEE, WW ;

TONG, E .

JOURNAL OF THEORETICAL BIOLOGY, 1962, 3 (03) :459-&

[2] IRREVERSIBLE ENZYME INHIBITORS .105. DIFFERENTIAL IRREVERSIBLE INHIBITION OF VERTEBRATE DIHYDROFOLIC REDUCTASES BY DERIVATIVES OF 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINES SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1967, 10 (06) :1113-+

[3] IRREVERSIBLE ENZYME INHIBITORS .115. PROTEOLYTIC ENZYMES .5. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF TRYPSIN DERIVED FROM P-(PHENOXYALKOXY)BENZAMIDINES WITH A TERMINAL SULFONYL FLUORIDE [J].

BAKER, BR ;

ERICKSON, EH .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (02) :245-&

[4] IRREVERSIBLE ENZYME INHIBITORS .113. PROTEOLYTIC ENZYMES .3. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF ALPHA-CHYMOTRYPSIN DERIVED FROM PHENOXYACETAMIDES WITH AN N-FLUOROSULFONYLPHENYL SUBSTITUENT [J].

BAKER, BR ;

HURLBUT, JA .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (02) :233-&

[5]

BAKER BR, 1968, J MED CHEM, V11, P666, DOI 10.1021/jm00310a007

[6] IRREVERSIBLE ENZYME INHIBITORS .119. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE WITH TISSUE SPECIFICITY DERIVED FROM 2,4,6-TRIAMINOPYRIMIDINE WITH A TERMINAL SULFONYL FLUORIDE AT 5 POSITION [J].

BAKER, BR ;

MEYER, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (03) :489-&

[7] ANALOGS OF TETRAHYDROFOLIC ACID .29. HYDROPHOBIC BONDING TO DIHYDROFOLIC REDUCTASE .2. ON MODE OF PHENYL BINDING OF 1-ARYL-4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZINES [J].

BAKER, BR ;

HO, BT .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1965, 2 (04) :335-&

[8] IRREVERSIBLE ENZYME INHIBITORS .88. DIFFERENTIAL IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM DIFFERENT SPECIES [J].

BAKER, BR ;

JORDAAN, JH .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1967, 56 (05) :660-&

[9] IRREVERSIBLE ENZYME INHIBITORS .129. P-(4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-S-TRIAZIN-1-YL)PHENYLPROPIONYLSULFANILYL FLUORIDE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE .V. EFFECTS OF SUBSTITUTION ON BENZENESULFONYL FLUORIDE MOIETY ON ISOZYME SPECIFICITY [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (04) :677-&

[10] IRREVERSIBLE ENZYME INHIBITORS .112. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-1-PHENYL-S-TRIAZINE SUBSTITUTED WITH A TERMINAL SULFONYL FLUORIDE .2. [J].

BAKER, BR ;

LOURENS, GJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (01) :38-&