FC-ALPHA-R EXPRESSION ON POLYMORPHONUCLEAR LEUKOCYTE AND SUPEROXIDE GENERATION IN IGA NEPHROPATHY

被引：37

作者：

KASHEM, A ^{[1
]}

ENDOH, M ^{[1
]}

NOMOTO, Y ^{[1
]}

SAKAI, H ^{[1
]}

NAKAZAWA, H ^{[1
]}

机构：

[1] TOKAI UNIV,DEPT PHYSIOL,ISEHARA,KANAGAWA,JAPAN

来源：

KIDNEY INTERNATIONAL | 1994年 / 45卷 / 03期

关键词：

D O I：

10.1038/ki.1994.114

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Superoxide (O-2(-)) production and Fc alpha R antigen expression of circulating polymorphonuclear leukocytes (PMNL) isolated from patients with IgA nephropathy (IgAN) and non-IgA mesangial proliferative glomerulonephritis (PGN) and healthy volunteers were investigated to establish their biological importance in the immunopathogenesis of mesangial proliferative glomerulonephritis. PMNL from both patient groups showed increased O-2(-) production when stimulated with N-formyl methionyl leucyl phenylalanine (FMLP) and phorbol myristate acetate (PMA). The increased O-2(-) generation demonstrated a positive correlation with the degree or proteinuria. Aggregated IgA caused enhanced O-2(-) production only in patients with IgAN who also showed a significant correlation with proteinuria. Increased expression of Fc alpha R on circulating PMNL was observed in IgAN patients as determined by flow cytometric analysis. The amount of Fc alpha R on PMNL was positively correlated with O-2(-) generation triggered with IgA aggregates. These results suggest that (1.) circulating PMNL may potentially be participating in the pathogenesis of glomerular injury in mesangial proliferative glomerulonephritis, and (2.) IgA aggregates/immune complexes may contribute to the immunopathogenesis of IgAN through augmenting the Fccu receptor-mediated generation of superoxide anion.

引用

页码：868 / 875

页数：8

共 34 条

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