CALCIUM-DEPENDENCE OF GLUTAMATE-RECEPTOR EVOKED ALKALINE SHIFTS IN HIPPOCAMPUS

被引：26

作者：

SMITH, SE

GOTTFRIED, JA

CHEN, JCT

CHESLER, M

机构：

[1] NYU,MED CTR,DEPT PHYSIOL & BIOPHYS,NEW YORK,NY 10016

[2] NYU,MED CTR,DEPT NEUROSURG,NEW YORK,NY 10016

来源：

NEUROREPORT | 1994年 / 5卷 / 18期

关键词：

HIPPOCAMPUS; NMDA; AMPA; GLUTAMATE; EXCITATORY SYNAPTIC TRANSMISSION; EXTRACELLULAR PH; CA2+-H+ EXCHANGE; GLUTAMATE UPTAKE;

D O I：

10.1097/00001756-199412000-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

GLUTAMATE receptor activation induces an extracellular alkalinization in rodent hippocampus. We studied its Ca2+ dependence and pharmacology in hippocampal slices. Glutamate-evoked alkaline shifts were blocked by 0 Ca2+ saline. Alkalinizations induced by AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and NMDA (N-methyl-D-aspartate) were abolished by 20 mu M CNQX (6-cyano-7-nitro-nitroquinoxaline-2,3-dione) and 50 mu M APV (DL-2-amino-5-phosphonovalerate), respectively. The AMPA- and NMDA-evoked alkaline shifts were blocked by 0 Ca2+, however, AMPA-induced [K+](0) elevation was unaffected. These data suggest that the glutamate receptor-channel does not mediate H+ influx, and support a role for Ca2+-H+ exchange.

引用

页码：2441 / 2445

页数：5

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