ANDROGEN-REGULATION OF ORNITHINE DECARBOXYLASE AND S-ADENOSYLMETHIONINE DECARBOXYLASE GENES

被引：33

作者：

JANNE, OA ^{[1
]}

CROZAT, A ^{[1
]}

PALVIMO, J ^{[1
]}

EISENBERG, LM ^{[1
]}

机构：

[1] ROCKEFELLER UNIV,NEW YORK,NY 10021

来源：

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1991年 / 40卷 / 1-3期

关键词：

D O I：

10.1016/0960-0760(91)90196-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are two key enzymes in polyamine biosynthesis. Both the ODC and the AdoMetDC gene is regulated by androgens in accessory sex organs of mice and rats, whereas only the ODC gene is androgen-responsive in rodent kidney. Androgenic responses in murine and rat kidneys are, however, dissimilar in that the induction of ODC activity and ODC mRNA accumulation is transient in the rat but sustained in the murine renal cells. In addition, in situ hybridization experiments with single-stranded cRNA probes revealed that ODC gene expression occurs in different subpopulations of epithelial cells of the proximal tubules in mice and rats. ODC and AdoMetDC genes are androgen-regulated in the same cell types of the accessory sex organs, as judged by hybridization histochemistry. Sequencing of the promotor region of the murine ODC gene has indicated the presence of several DNA elements for binding of transcription factors/regulatory proteins, including a putative androgen-response element at about 900 nucleotides upstream of the transcription start site.

引用

页码：307 / 315

页数：9

共 46 条

[11] CHARACTERIZATION AND SEQUENCE-ANALYSIS OF THE HUMAN ORNITHINE DECARBOXYLASE GENE [J].