SYMMETRIC BILATERAL CHANGES IN DOPAMINE RELEASE FROM THE CAUDATE NUCLEI OF THE CAT INDUCED BY UNILATERAL NIGRAL APPLICATION OF GLYCINE AND GABA-RELATED COMPOUNDS

The release of [3H]DA synthesized from [3H] tyrosine was estimated in the two caudate nuclei (CN) during the unilateral nigral application of glycine and GABA-related compounds in 'encéphale isolé' cats using push-pull cannulae. Glycine (10-5 M) reduced the release of [3H]DA release was also seen in both CN during strychnine (10-5 M). A decrease in [3H]DA release was also seen in both CN during the unilateral nigral application of diazepam (10-5 M). In contrast, muscimol (10-6 M) and GABA (10-5 M) stimulated [3H]DA release on both sides. The effect of GABA was blocked by picrotoxin (10-5 M). Picrotoxin alone stimulated the release of [3H]DA in the ipsilateral CN and was without effect in the contralateral side. Bicuculline (10-5 M) stimulated [3H]DA release only in the contralateral CN. A symmetric increase in [3H]DA release in both CN was also observed during the unilateral nigral application of potassium (30 mM). A model involving a facilitatory polysynaptic pathway originating from the substantia nigra (SN) and acting presynaptically on the terminals of the contralateral DA neurons is proposed to explain the changes in [3H]DA release induced in the contralateral CN in these various situations. The results are discussed taking into account previous data on the reciprocal control of the two dopaminergic pathways induced by the unilateral nigral application of dopaminergic drugs. © 1979.