GLUTAMATE NEUROTOXICITY IN THE DEVELOPING RAT COCHLEA IS ANTAGONIZED BY KYNURENIC ACID AND MK-801

被引:17
作者
JANSSEN, R
机构
[1] Neurotoxicology Division MD 74B, US Environmental Protection Agency, Research Triangle Park
关键词
COCHLEA; GLUTAMATE; EXCITOTOXICITY; GLUTAMATE NEUROTOXICITY; OTOTOXICITY; KYNURENIC ACID; MK-801;
D O I
10.1016/0006-8993(92)91096-W
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Glutamate (Glu) is neurotoxic in the neonatal rat cochlea, producing hearing impairment which is largely due to the death of spiral ganglion cells, whereas the receptor hair cells are spared. Dendritic processes of the spiral ganglion are postsynaptic to the primary afferent synapse of the auditory system. The experiments reported here were designed to test whether this apparent excitotoxicity can be blocked by Glu antagonists. The broad-spectrum antagonist kynurenic acid (KYNA) was coadministered with Glu initially to determine whether the high-frequency hearing deficit caused by Glu may be mediated by excitatory amino acid receptors. Subsequently, the N-methyl-D-aspartate (NMDA)-specific receptor blocker MK-801 was used to test whether NMDA receptors may be involved in the effect. Both antagonists partially blocked the high-frequency hearing impairment caused by Glu. The blocker-alone control groups exhibited mid-frequency effects of unknown origin. The significant antagonism of Glu-induced impairment is consistent with the hypothesis that Glu or a similar excitatory amino acid is an important afferent transmitter in the cochlea.
引用
收藏
页码:201 / 206
页数:6
相关论文
共 52 条
  • [41] THE EFFECT OF NEONATALLY ADMINISTERED MONOSODIUM GLUTAMATE (MSG) ON THE DEVELOPMENT OF RETINOFUGAL PROJECTIONS AND THE ENTRAINMENT OF CIRCADIAN LOCOMOTOR-ACTIVITY
    PICKARD, GE
    TUREK, FW
    LAMPERTI, AA
    SILVERMAN, AJ
    [J]. BEHAVIORAL AND NEURAL BIOLOGY, 1982, 34 (04): : 433 - 444
  • [42] MONOSODIUM GLUTAMATE ADMINISTRATION TO NEWBORN REDUCES REPRODUCTIVE ABILITY IN FEMALE AND MALE MICE
    PIZZI, WJ
    BARNHART, JE
    FANSLOW, DJ
    [J]. SCIENCE, 1977, 196 (4288) : 452 - 454
  • [43] SUPPRESSION OF AUDITORY-NERVE ACTIVITY IN THE GUINEA-PIG COCHLEA BY 1-(PARA-BROMOBENZOYL)-PIPERAZINE-2,3-DICARBOXYLIC ACID
    PUEL, JL
    BOBBIN, RP
    FALLON, M
    [J]. BRAIN RESEARCH, 1989, 487 (01) : 9 - 15
  • [44] ELECTROPHYSIOLOGICAL EVIDENCE FOR THE PRESENCE OF NMDA RECEPTORS IN THE GUINEA-PIG COCHLEA
    PUEL, JL
    LADRECH, S
    CHABERT, R
    PUJOL, R
    EYBALIN, M
    [J]. HEARING RESEARCH, 1991, 51 (02) : 255 - 264
  • [45] KAINIC ACID SELECTIVELY ALTERS AUDITORY DENDRITES CONNECTED WITH COCHLEAR INNER HAIR-CELLS
    PUJOL, R
    LENOIR, M
    ROBERTSON, D
    EYBALIN, M
    JOHNSTONE, BM
    [J]. HEARING RESEARCH, 1985, 18 (02) : 145 - 151
  • [46] TRANSIENT INCREASE OF NMDA-BINDING SITES IN HUMAN HIPPOCAMPUS DURING DEVELOPMENT
    REPRESA, A
    TREMBLAY, E
    BENARI, Y
    [J]. NEUROSCIENCE LETTERS, 1989, 99 (1-2) : 61 - 66
  • [47] EFFECT OF PERINATAL MONOSODIUM GLUTAMATE ADMINISTRATION ON VISUAL EVOKED-POTENTIALS OF JUVENILE AND ADULT-RATS
    RIGDON, GC
    BOYES, WK
    DYER, RS
    [J]. NEUROTOXICOLOGY AND TERATOLOGY, 1989, 11 (02) : 121 - 128
  • [48] EXCITOTOXICITY AND THE NMDA RECEPTOR
    ROTHMAN, SM
    OLNEY, JW
    [J]. TRENDS IN NEUROSCIENCES, 1987, 10 (07) : 299 - 302
  • [49] SCHWARCZ R, 1988, FRONTIRS AMINO ACID
  • [50] SERESS L, 1984, CELL TISSUE RES, V235, P453