MICROBIAL REDUCTION OF 1-TETRALONE 2-CARBOXYESTERS AS A SOURCE OF NEW ASYMMETRIC SYNTHONS

被引：34

作者：

BUISSON, D

CECCHI, R

LAFFITTE, JA

GUZZI, U

AZERAD, R

机构：

[1] SANOFI MIDY SPA,CTR RECH,I-20137 MILAN,ITALY

[2] GRP RECH LACQ,SERV CHIM ENZYMAT,F-64170 LACQ,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 19期

关键词：

D O I：

10.1016/S0040-4039(00)76837-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reduction of unsubstituted or methoxy-substituted (+/-)-2-carboxyethyl-1-tetralones by selected microorganisms affords optically active 1-hydroxy-2-carboxyethyl tetralins which can be used as versatile asymmetric synthons, for example in the preparation of biologically active methoxy-substituted 2R-aminotetralins. 1R,2R-(cis)-hydroxyesters of high optical purity are obtained with yeast strains, while the use of filamentous fungi leads to the enantiomeric 1S,2S-(cis)-hydroxyesters.

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页码：3091 / 3094

页数：4

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