MICROBIAL REDUCTION OF 2-CHLORO-3-ARYL-3-OXOPROPIONIC ACID-ESTERS

被引:23
作者
CABON, O
LARCHEVEQUE, M
BUISSON, D
AZERAD, R
机构
[1] ECOLE NORM SUPER,CHIM LAB,CNRS,UNITE PROPRE,24 RUE LHOMOND,F-75231 PARIS 05,FRANCE
[2] UNIV R DESCARTES,CNRS,CHIM & BIOCHIM PHARMACOL & TOXICOL LAB,F-75270 PARIS 06,FRANCE
关键词
2-CHLORO-3-KETOESTERS; 2,3-EPOXYESTERS; MICROBIAL REDUCTIONS; BAKER YEAST; MUCOR-RACEMOSUS; RHODOTORULA-GLUTINIS;
D O I
10.1016/S0040-4039(00)60181-8
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
2-Chloro-3-aryl-3-oxopropionic acid esters are reduced by microorganisms to syn- and/or anti-2-chloro-3-hydroxy-3-arylpropionates, in competition with dechlorination and decarboxylation reactions. Using selected strains, it is possible to obtain enantiomerically pure chlorohydroxyesters, which were converted to the corresponding phenylglycidic esters with high stereospecificity.
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页码:7337 / 7340
页数:4
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