LISURIDE HYDROGEN MALEATE - ERGOLINE WITH BETA-ADRENERGIC ANTAGONIST ACTIVITY

被引：12

作者：

COTE, T

MUNEMURA, M

KEBABIAN, J

机构：

[1] Experimental Therapeutics Branch, National Institute of Neurlogical and Communicative Disorders and Stroke, National Institutes of Health, Bethesda, MD 20205, Building 10

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 59卷 / 3-4期

基金：

美国国家卫生研究院;

关键词：

Adenylate cyclase; Dihydroalprenolol; Lisuride; Spiroperidol; β-Adrenoceptor;

D O I：

10.1016/0014-2999(79)90295-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Lisuride hydrogen maleate is identified as a potent β-adrenergic antagonist using a hormone-sensitive adenylate cyclase system and [3H]dihydroalprenolol binding in cell free homogenates of rabbit cerebellum. Lisuride and two other egolines, lergotrile and bromocriptine, and the phenothiazine, fluphenazine, all interact with spiroperidol bindig sites (dopamine_receptors) in the anterior pitiutary; however, among these compounds lisuride is unique in its ability to antagonize the β-adrenoceptor. © 1979.

引用

页码：303 / 306

页数：4

共 10 条

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