DECREASED INSULIN SENSITIVITY IN OFFSPRING WHOSE PARENTS BOTH HAVE TYPE-2 DIABETES

被引：25

作者：

RAMACHANDRAN, A

SNEHALATHA, C

MOHAN, V

BHATTACHARYYA, PK

VISWANATHAN, M

机构：

[1] Diabetes Research Centre, M. V. Hospital for Diabetes, Madras, Royapuram

来源：

DIABETIC MEDICINE | 1990年 / 7卷 / 04期

关键词：

Insulin response; Insulin sensitivity; Insulin tolerance test; Offspring; Type; 2; diabetes;

D O I：

10.1111/j.1464-5491.1990.tb01400.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Offspring of two Type 2 diabetic parents have a high prevalence of diabetes and impaired glucose tolerance. Studies in normoglycaemic offspring have shown abnormal insulin responses. Twenty‐four non‐obese offspring having normal oral glucose tolerance were investigated by the insulin tolerance test for abnormalities of insulin sensitivity. Plasma insulin responses were measured during an oral glucose tolerance test. Although the plasma glucose responses during the OGTT were similar to the control values, the corresponding insulin responses were higher. The mean area under the insulin curve was 121 ± 29 (± SD) mU I−1 h in the control subjects and 203 ± 73 mU I−1 h in the offspring (p < 0.001). The mean KITT value in the offspring was 4.3 ± 1.9 min−1 × 100 which was significantly lower (p < 0.01) than the value of 6.2 ± 2.0 min−1 × 100 in the control subjects. The results suggest that some offspring of two Type 2 diabetic parents have low insulin sensitivity and the presence of hyperinsulinism may be a compensatory phenomenon. 1990 Diabetes UK

引用

页码：331 / 334

页数：4

共 18 条

[11]

Stern MP., Type 2 diabetes mellitus. Interface between clinical and epidemiological investigation, Diabetes Care, 11, pp. 119-126, (1988)

[12]

Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK., Increased insulin concentrations in non‐diabetic offspring of diabetic parents, N Engl J Med, 319, pp. 1297-1301, (1988)

[13]

Leslie RDG, Volkmann HP, Poncher M., Hanning I., Orskov H., Alberti KGMM., Metabolic abnormalities in children of non‐insulin dependent diabetics, Br Med J, 293, pp. 840-842, (1986)

[14]

Aronoff SL, Bennett PH, Gorden P., Rushforth N., Miller M., Unexplained hyperinsulinaemia in normal and ‘pre‐diabetic’ Pima Indians compared with normal Caucasians: an example of racial differences in insulin secretion, Diabetes, 26, pp. 827-840, (1977)

[15]

DeFronzo RA, Ferrannini E., Koivisto V., New concepts in the pathogenesis and treatment of non‐insulin dependent diabetes mellitus, Am J Med, 74, pp. 52-81, (1983)

[16]

Sicree RA, Zimmet PZ, King KOM, Coventry JS., Plasma insulin response among Nauruans: prediction of deterioration in glucose tolerance over six years, Diabetes, 36, pp. 179-186, (1987)

[17]

Bogardus C., Lillioja S., Nyomba BL, Et al., Evidence for a single gene, co‐dominant mode of inheritance of insulin resistance in Pima Indians (Abstract), Diabetes, 37, (1988)

[18]

McClain DA, Henry RR, Ullrich A., Olefsky JM., Restriction‐fragment‐length polymorphism in insulin‐receptor gene and insulin resistance in NIDDM, Diabetes, 37, pp. 1071-1075, (1988)

← 1 2 →