GENETIC-DIFFERENCES IN ETHANOL-INDUCED HYPERGLYCEMIA AND CONDITIONED TASTE-AVERSION

被引：47

作者：

RISINGER, FO

CUNNINGHAM, CL

机构：

[1] Department of Medical Psychology (L470) Oregon Health Sciences University Portland

来源：

LIFE SCIENCES | 1992年 / 50卷 / 16期

关键词：

D O I：

10.1016/0024-3205(92)90463-Y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Genetic differences in the hyperglycemic response to acute ethanol exposure and ethanol-induced conditioned taste aversion were examined using inbred mice. Adult male C57BL/6J and DBA/2J mice were injected with ethanol (0-6 g/kg, I.P.) and blood glucose levels determined over 4 h. C57 mice demonstrated greater dose-dependent elevations in blood glucose compared to DBA mice. In a conditioned taste aversion procedure, water deprived mice received ethanol injections (1-4 g/kg, I.P.) immediately after access to a NaCl flavored solution. DBA mice developed aversion to the ethanol-paired flavor at a lower dose (2 g/kg) than C57 mice. These results provide further support for a possible inverse genetic relationship between sensitivity to ethanol-induced hyperglycemia and sensitivity to conditioned taste aversion.

引用

页码：PL113 / PL118

页数：6

共 15 条

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