DNA-REPLICATION - ENZYMOLOGY AND MECHANISMS

被引：64

作者：

KELMAN, Z

ODONNELL, M

机构：

[1] Department of Microbiology, Cornell University Medical College, New York, NY 10021

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1994年 / 4卷 / 02期

关键词：

D O I：

10.1016/S0959-437X(05)80044-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Research into the enzymology of DNA replication has seen a multitude of highly significant advances during the past year, in both prokaryotic and eukaryotic systems. The scope of this article is limited to chromosomal replicases and origins of initiation. The multiprotein chromosomal replicases of prokaryotes and eukaryotes appear to be strikingly similar in structure and function, although future work may reveal their differences. Recent developments, elaborating the activation of origins in several systems, have begun to uncover mechanisms of regulation. The enzymology of eukaryotic origins has, until now, been limited to viral systems, but over the past few years, enzymology has caught a grip on the cellular origins of yeast.

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页码：185 / 195

页数：11

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