THE ROLE OF O-2-CENTER-DOT- IN THE PRODUCTION OF HO-CENTER-DOT - IN-VITRO AND IN-VIVO

被引：366

作者：

LIOCHEV, SI

FRIDOVICH, I

机构：

[1] DUKE UNIV,MED CTR,DEPT BIOCHEM,DURHAM,NC 27710

[2] BULGARIAN ACAD SCI,INST PHYSIOL,BU-1113 SOFIA,BULGARIA

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 1994年 / 16卷 / 01期

关键词：

HYDROXYL RADICAL; DEHYDRATASES; ACONITASE; SUPEROXIDE; FREE RADICALS;

D O I：

10.1016/0891-5849(94)90239-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In vitro O2.- reduces Fe(III) to Fe(II), which, in turn, reduces the H2O2, yielding Fe(II)O or HO.. In vivo O2.-increases the supply of free iron by oxidatively attacking the [4Fe-4S] clusters of dehydratases such that they release Fe(II), which can then reduce H2O2. In vivo. O2.- also increases the production of H2O2 by acting as an oxidant toward the dehydratases and toward other cellular reductants.

引用

页码：29 / 33

页数：5

共 63 条

[1] LACTOFERRIN ENHANCES HYDROXYL RADICAL PRODUCTION BY HUMAN-NEUTROPHILS, NEUTROPHIL PARTICULATE FRACTIONS, AND AN ENZYMATIC GENERATING-SYSTEM [J].