学术探索
学术期刊
新闻热点
数据分析
智能评审

BIOCATALYTIC SYNTHESIS OF CHIRAL POLYOXYGENATED COMPOUNDS - MODULATION OF THE SELECTIVITY UPON CHANGES IN THE EXPERIMENTAL CONDITIONS

被引：22
作者：
HERRADON, B
VALVERDE, S
机构：
[1] Instituto de Química Orgánica, C. S. I. C., cl Juan de la Cierva 3
来源：
TETRAHEDRON-ASYMMETRY | 1994年 / 5卷 / 08期
关键词：
D O I：
10.1016/0957-4166(94)80118-5
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Derivatives of both enantiomers of butane-1,2,4-triol have been obtained through a transesterification reaction catalyzed by Pseudomonas fluorescens lipase (PFL) in organic solvents. The influence of the solvent on the enantioselectivity has been thoroughly examined. It has been found that the enantioselectivity depends on both the hydrophobicity and the polarity of the solvent in a semi-quantitative way. The influence of other experimental variables (temperature, amounts of lipase and acylating agent, addition of water, addition of molecular sieves) on the enantioselectivity has also been investigated.
引用
收藏
页码：1479 / 1500
页数：22
相关论文
共 124 条
3456789101112