EFFECT OF 1-BETA-D-ARABINOFURANOSYL-E-5-(2-BROMOVINYL)URACIL AGAINST HERPES-SIMPLEX VIRUS TYPE-1 INFECTION IN IMMUNOSUPPRESSED MICE

被引：4

作者：

IJICHI, K ^{[1
]}

ASHIDA, N ^{[1
]}

MACHIDA, H ^{[1
]}

机构：

[1] YAMASA SHOYU CO LTD,DIV RES & DEV,BIOL LAB,CHOSHI 288,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 12期

关键词：

D O I：

10.1128/AAC.34.12.2431

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

1-β-D-Arabinofuranosyl-E-5-(2-bromovinyl)uracil (BV-araU) reduced the mortality rates of (i) 7-week-old, cyclophosphamide-treated, immunosuppressed mice (CYP mice) intraperitoneally infected with a moderately virulent strain of herpes simplex virus type 1 and (ii) 4-week-old CYP mice infected with a less virulent strain at doses of 20 and 50 mg/kg of body weight twice daily and 5 mg/kg, respectively. The degree of efficacy of BV-araU was equivalent to that of acyclovir in 4-week-old CYP mice infected with the less virulent strain. BV-araU (20 mg/kg) suppressed viral growth in various organs of CYP mice.

引用

页码：2431 / 2433

页数：3