CATALYTIC-OXIDATION OF CHLORPROMAZINE AND RELATED PHENOTHIAZINES - CATION RADICALS AS THE REACTIVE INTERMEDIATES IN SULFOXIDE INFORMATION

被引：48

作者：

BOSCH, E

KOCHI, JK

机构：

[1] Chemistry Department, University of Houston, Houston

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1995年 / 08期

关键词：

D O I：

10.1039/p19950001057

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aerial oxidation of various phenothiazines to the corresponding sulfoxides is catalysed by nitric oxide and related nitrogen oxides. The reactive intermediate in the catalytic autoxidation is the phenothiazine cation radical which is subsequently transformed to the sulfoxide by nitrate present in the reaction medium. These results are pertinent to any further discussion of the activity and/or metabolism of phenothiazine-based drugs.

引用

页码：1057 / 1064

页数：8

共 80 条

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