UBIQUITINATION AS A PROBE FOR NEURODEGENERATION IN THE BRAIN IN SCHIZOPHRENIA - THE PREFRONTAL CORTEX

被引：15

作者：

HORTON, K

FORSYTH, CS

SIBTAIN, N

BALL, S

BRUTON, CJ

ROYSTON, MC

ROBERTS, GW

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT, COLDHARBOUR RD, HARLOW CM19 5AD, ESSEX, ENGLAND

[2] RUNWELL HOSP, ESSEX, ENGLAND

[3] CHARING CROSS & WESTMINSTER MED SCH, DEPT PSYCHIAT, LONDON W6 8RP, ENGLAND

[4] CHARING CROSS & WESTMINSTER MED SCH, DEPT ANAT, LONDON W6 8RP, ENGLAND

[5] UNIV MANCHESTER, DEPT PHYSIOL SCI, MANCHESTER M20 9PT, ENGLAND

来源：

PSYCHIATRY RESEARCH | 1993年 / 48卷 / 02期

基金：

英国惠康基金;

关键词：

UBIQUITIN; FRONTAL LOBE; POSTMORTEM STUDIES; NEURODEVELOPMENT; PATHOLOGY;

D O I：

10.1016/0165-1781(93)90038-I

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Abnormalities in brain structure and brain function have been described in schizophrenia. It is not vet known whether these are caused by an abnormality of brain development, some form of birth injury, or a neurodegenerative process. Using immunocytochemical methods and a marker for neurodegeneration (ubiquitin), we examined an area of prefrontal cortex from elderly schizophrenic and control subjects for the presence of ubiquitin-positive degeneration products. There was no statistical difference in the degree of ubiquitination between the control and the patient samples. The findings provide no evidence to support a neurodegenerative process.

引用

页码：145 / 152

页数：8