NOVEL SYNTHETIC ROTENOIDS WITH BLOCKED B/C RING-SYSTEMS

被引：6

作者：

JOSEPHS, JL ^{[1
]}

CASIDA, JE ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT ENTOMOL SCI,PESTICIDE CHEM & TOXICOL LAB,BERKELEY,CA 94720

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(01)81204-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The novel cis-12a-methylrotenone is much more potent than its trans epimer as an insecticide and inhibitor of NADH dehydrogenase, establishing the importance of the cis-B/C ring system for biological activity. Blocking the B/C ring fusion of rotenone with either the 12a-methyl or the 6a,12a-cyclopropyl substituent greatly increases the photostability and the 12a-methyl compound also has remarkably enhanced toxicity to houseflies.

引用

页码：593 / 596

页数：4

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