CHANGES IN WATER DIFFUSION AND RELAXATION PROPERTIES OF RAT CEREBRUM DURING STATUS EPILEPTICUS

被引：186

作者：

ZHONG, J ^{[1
]}

PETROFF, OAC ^{[1
]}

PRICHARD, JW ^{[1
]}

GORE, JC ^{[1
]}

机构：

[1] YALE UNIV, SCH MED, DEPT NEUROL, NEW HAVEN, CT 06510 USA

来源：

MAGNETIC RESONANCE IN MEDICINE | 1993年 / 30卷 / 02期

关键词：

MRI; WATER DIFFUSION COEFFICIENT; STATUS EPILEPTICUS; BRAIN;

D O I：

10.1002/mrm.1910300214

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Diffusion-weighted (DW) imaging has been used to record changes associated with status epilepticus (SE) in rat brain. It was found that the apparent diffusion coefficient (ADC) of water in brain decreased 14-18% during SE, and it fell a further 20-22% when the animals were sacrificed. The transverse decay time constant T2* showed corresponding reductions, but no significant changes were seen in relaxation times T1 or T2 values. Changes in ADC in status epilepticus are similar to those seen in stroke and ischemia but occur under very different conditions of blood flow and metabolism.

引用

页码：241 / 246

页数：6

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