EIGENSTRUCTURE TRACKING ANALYSIS FOR ASSESSMENT OF PEAK PURITY IN HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH DIODE-ARRAY DETECTION

被引：17

作者：

SANCHEZ, FC

TOFT, J

KVALHEIM, OM

MASSART, DL

机构：

[1] FREE UNIV BRUSSELS,CHEMOAC,B-1090 BRUSSELS,BELGIUM

[2] UNIV BERGEN,DEPT CHEM,N-5007 BERGEN,NORWAY

来源：

ANALYTICA CHIMICA ACTA | 1995年 / 314卷 / 03期

关键词：

LIQUID CHROMATOGRAPHY; PRINCIPAL COMPONENT ANALYSIS; PEAK PURITY; EIGENSTRUCTURE TRACKING ANALYSIS; SPECTRUM NORMALIZATION;

D O I：

10.1016/0003-2670(95)00280-D

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The application of eigenstructure tracking analysis (ETA) for the detection of an impurity under a chromatographic peak is discussed. A window of size three seems to be the most adequate for this problem. Some guidelines for interpretation of the ETA plots are given. A new normalization of spectra is proposed to remove heteroscedastic noise. The effect of this new normalization is compared with other data pretreatments. The results obtained are compared with the performance of methods such as fixed size window evolving factor analysis (FSW EFA), the methods based on the Gram-Schmidt orthogonalization and SIMPLISMA.

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页码：131 / 139

页数：9

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