ALGORITHM FOR THE ASSESSMENT OF PEAK PURITY IN LIQUID-CHROMATOGRAPHY WITH PHOTODIODE-ARRAY DETECTION

被引：53

作者：

SANCHEZ, FC

KHOTS, MS

MASSART, DL

DEBEER, JO

机构：

[1] VRIJE UNIV BRUSSELS,INST PHARMACEUT,LAARBEEKLAAN 103,B-1090 BRUSSELS,BELGIUM

[2] INST HYG & EPIDEMIOL,B-1050 BRUSSELS,BELGIUM

来源：

ANALYTICA CHIMICA ACTA | 1994年 / 285卷 / 1-2期

关键词：

LIQUID CHROMATOGRAPHY; PRINCIPAL COMPONENT ANALYSIS; DETECTION LIMITS; ORTHOGONALIZATION; PEAK PURITY CONTROL;

D O I：

10.1016/0003-2670(94)85022-4

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An algorithm for peak purity analysis based on the Gram-Schmidt orthogonalization method is described. The data are pretreated by using two different normalization techniques. The performance of this approach is investigated for liquid chromatography with photodiode-array detection (LC-DAD) data. The results are compared with the ones obtained by means of fixed size window evolving factor analysis (FSW EFA). The effects of heteroscedasticity and non linearities are discussed.

引用

页码：181 / 192

页数：12

共 21 条

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