ASSESSMENT OF PEAK HOMOGENEITY IN LIQUID-CHROMATOGRAPHY USING MULTIVARIATE CHEMOMETRIC TECHNIQUES

被引：18

作者：

KELLER, HR

KIECHLE, P

ERNI, F

MASSART, DL

EXCOFFIER, JL

机构：

[1] SANDOZ PHARMA AG,ANALYT RES & DEV,CH-4002 BASEL,SWITZERLAND

[2] VRIJE UNIV BRUSSELS,INST PHARMACEUT,B-1090 BRUSSELS,BELGIUM

[3] VARIAN CHROMATOG SYST,WALNUT CREEK,CA 94598

来源：

JOURNAL OF CHROMATOGRAPHY | 1993年 / 641卷 / 01期

关键词：

D O I：

10.1016/0021-9673(93)83452-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The performance of three new chemometric techniques was evaluated systematically for assessment of peak homogeneity in liquid chromatography with photodiode-array detection. Multi-component analysis, window evolving factor analysis and the HELP method performed equally well in this study. Without making any assumption about peak shape or spectra, these methods were able to detect less than 1% of a spectrally similar impurity under a chromatographic peak, even if the chromatographic separation was low. The limitations of these techniques are also discussed.

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页码：1 / 9

页数：9

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