THE FUNCTIONAL NEUROANATOMY OF TOURETTES-SYNDROME - AN FDG-PET STUDY .1. REGIONAL CHANGES IN CEREBRAL GLUCOSE-METABOLISM DIFFERENTIATING PATIENTS AND CONTROLS

被引：138

作者：

BRAUN, AR

STOETTER, B

RANDOLPH, C

HSIAO, JK

VLADAR, K

GERNERT, J

CARSON, RE

HERSCOVITCH, P

CHASE, TN

机构：

[1] NIND, EXPTL THERAPEUT BRANCH, BETHESDA, MD USA

[2] NIMH, EXPTL THERAPEUT BRANCH, BETHESDA, MD 20892 USA

[3] NIH, CTR CLIN, DEPT PET, BETHESDA, MD 20892 USA

[4] ST ELIZABETH HOSP, NIMH, CTR NEUROSCI, CLIN BRAIN DISORDERS BRANCH, WASHINGTON, DC 20032 USA

[5] GEORGE WASHINGTON UNIV, DEPT PSYCHOL, WASHINGTON, DC 20052 USA

来源：

NEUROPSYCHOPHARMACOLOGY | 1993年 / 9卷 / 04期

关键词：

TOURETTES SYNDROME; POSITRON-EMISSION TOMOGRAPHY; (18)[F]-FLUORODEOXYGLUCOSE; MOVEMENT DISORDERS; BASAL GANGLIA; PREMOTOR; MOTOR; LIMBIC;

D O I：

10.1038/npp.1993.64

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Regional metabolic rates for glucose estimated using [F-18]fluorodeoxyglucose positron-emission tomography were compared in 16 drug-free patients with Tourette's syndrome (TS) and 16 age- and sex-matched normal volunteers. Tourette's syndrome patients were characterized by decreased normalized metabolic rates in paralimbic and ventral prefrontal cortices, particularly in orbitofrontal, inferior insular, and parahippocampal regions. Similar decreases were observed in subcortical regions, including the ventral striatum (nucleus accumbens/ventromedial caudate) and in the midbrain, These changes were more robust and occurred with greater frequency in the left hemisphere. They were associated with concomitant bilateral increases in metabolic activity the supplementary motor, lateral premotor, and Rolandic cortices. Effects of prior exposure to neuroactive drugs did not account for these findings. These results suggest that an altered relationship between limbic-related regions of the cortex and striatum and cortical regions involved in the initiation of movement may play a role in the pathogenesis of this illness.

引用

页码：277 / 291

页数：15

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