KNOWLEDGE-BASED PROTEIN MODELING

被引：205

作者：

JOHNSON, MS

SRINIVASAN, N

SOWDHAMINI, R

BLUNDELL, TL

机构：

[1] Imperial Cancer Research Fund Unit of Structural Molecular Biology, Department of Crystallography, Birkbeck College, London

来源：

CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY | 1994年 / 29卷 / 01期

关键词：

COMPARATIVE MODELING; PROTEINS; 3-DIMENSIONAL STRUCTURES; AMINO ACID SEQUENCES; STRUCTURE ANALYSIS; DATA BANKS; SEARCHING; ALIGNMENTS;

D O I：

10.3109/10409239409086797

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Knowledge, both from the three-dimensional structures of homologous proteins and from the general analysis of protein structure, is of value in modeling a protein of known sequence but unknown structure. While many models are still constructed at least in part by manual methods on graphics devices, automated procedures have come into greater use. These procedures include those that assemble fragments of structure from other known structures and those that derive coordinates for the model from the satisfaction of restraints placed on atomic positions.

引用

页码：1 / 68

页数：68

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