ADENO-ASSOCIATED PARVOVIRUSES INHIBIT GROWTH OF CELLS DERIVED FROM MALIGNANT HUMAN-TUMORS

被引：32

作者：

BANTELSCHAAL, U ^{[1
]}

机构：

[1] UNIV FREIBURG, INST MED MIKROBIOL & HYG, VIROL ABT, W-7800 FREIBURG, GERMANY

来源：

INTERNATIONAL JOURNAL OF CANCER | 1990年 / 45卷 / 01期

关键词：

D O I：

10.1002/ijc.2910450134

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Infection of freshly established malignant human tumor cells with the adeno‐associated viruses AAV‐2 or AAV‐5 inhibits cell proliferation. Normal human fibroblasts are also affected, but appear to partially escape the inhibition. In cell cultures of permanent lines of human and rodent origin, cell number reduction could not be observed. The AAV‐mediated influence on cell growth is not due to helper‐independent replication of the virus, since neither of the cell cultures supported AAV propagation in the absence of a viral helper. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company

引用

页码：190 / 194

页数：5

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