HUMAN LYMPHOCYTES-T SYNTHESIZE AND SECRETE A PROTEASE RESISTANT PROTEOGLYCAN IN A DELAYED, SERUM-DEPENDENT RESPONSE TO CONCANAVALIN-A

被引：4

作者：

CHOPRA, R ^{[1
]}

GRIFFITH, E ^{[1
]}

IRWIN, D ^{[1
]}

ANASTASSIADES, T ^{[1
]}

机构：

[1] QUEENS UNIV,DEPT BIOCHEM,KINGSTON K7L 3N6,ONTARIO,CANADA

来源：

CELL BIOLOGY INTERNATIONAL REPORTS | 1991年 / 15卷 / 01期

关键词：

D O I：

10.1016/0309-1651(91)90079-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the presence of radioactive precursors, the addition of Concanavalin A (Con A) to cultures of mononuclear cells (MC) from human blood resulted in marked accumulation in the medium of a protease-resistant proteoglycan (PG) with chondroitin sulfate (CS) chains of an average molecular weight of 28 KDa. This PG was shown to be elaborated primarily by T-cells. The addition of serum was necessary for maximal stimulation with Con A and under these conditions PG accumulation in the medium rose slowly during the first few days of culture and much more rapidly between days 6-8. © 1991.

引用

页码：25 / 35

页数：11

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