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CHARACTERIZATION OF THE COLD-SENSITIVE MURINE HEPATITIS-VIRUS MUTANTS RESCUED FROM LATENTLY INFECTED-CELLS BY CELL-FUSION
被引:38
作者
:
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
STOHLMAN, SA
SAKAGUCHI, AY
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
SAKAGUCHI, AY
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
WEINER, LP
机构
:
[1]
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
[2]
UNIV SO CALIF,SCH MED,DEPT NEUROL,LOS ANGELES,CA 90033
来源
:
VIROLOGY
|
1979年
/ 98卷
/ 02期
关键词
:
D O I
:
10.1016/0042-6822(79)90567-1
中图分类号
:
Q93 [微生物学];
学科分类号
:
071005 ;
100705 ;
摘要
:
Mouse hepatitis virus, a coronavirus, was rescued from latently infected mouse neuroblastoma cells by polyethylene glycol-induced fusion to permissive cells. The isolated viruses grew to equal or higher titers than parental JHM virus at 39° but were restricted in replication at 32° and hence were cold-sensitive mutants. Neither isolate synthesized RNA at the nonpermissive temperature (32°), and temperature shift experiments indicated that the restrictive cold-sensitive step in replication occurred during an early viral function. The isolates were unable to complement each other at 32°. Although coinfection between each mutant and parental JHM virus often resulted in decreased yields of both infecting viruses, interference could not be convincingly demonstrated. Both mutants were more thermostable than parental JHM virus and could be distinguished from each other and from parental JHM virus by their thermal inactivation kinetics. The isolates were obtained from single cell clones and therefore presumed to be homogeneous; however, thermal inactivation of one (S-3JHM) indicated the possible existence of a second population. Subclones of virus prepared from each isolate were also found to be thermally stable and to retain the cold sensitive defect. No indication of a second population of S-3JHM virus was detected. © 1979.
引用
收藏
页码:448 / 455
页数:8
相关论文
共 20 条
[11]
SOMMERS K, 1973, P NAT ACAD SCI US, V70, P2206
[12]
STABILITY OF NEUROTROPIC MOUSE HEPATITIS VIRUS (JHM STRAIN) DURING CHRONIC INFECTION OF NEUROBLASTOMA-CELLS
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
STOHLMAN, SA
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
WEINER, LP
[J].
ARCHIVES OF VIROLOGY,
1978,
57
(01)
: 53
-
61
[13]
RESCUE OF A POSITIVE STRANDED RNA VIRUS FROM ANTIGEN NEGATIVE NEURO-BLASTOMA CELLS
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
STOHLMAN, SA
SAKAGUCHI, AY
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
SAKAGUCHI, AY
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
WEINER, LP
[J].
LIFE SCIENCES,
1979,
24
(11)
: 1029
-
1035
[14]
ENHANCED GROWTH OF A MURINE CORONAVIRUS IN TRANSFORMED MOUSE CELLS
STURMAN, LS
论文数:
0
引用数:
0
h-index:
0
STURMAN, LS
TAKEMOTO, KK
论文数:
0
引用数:
0
h-index:
0
TAKEMOTO, KK
[J].
INFECTION AND IMMUNITY,
1972,
6
(04)
: 501
-
&
[15]
TERMEULEN V, 1970, CURR TOP MICROBIOL I, V57, P1
[16]
WALKER DL, 1964, PROG MED VIROL, V6, P111
[17]
PATHOGENESIS OF DEMYELINATION INDUCED BY A MOUSE HEPATITIS VIRUS (JHM VIRUS)
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED,DEPT NEUROL, BALTIMORE, MD 21205 USA
JOHNS HOPKINS UNIV, SCH MED,DEPT NEUROL, BALTIMORE, MD 21205 USA
WEINER, LP
[J].
ARCHIVES OF NEUROLOGY,
1973,
28
(05)
: 298
-
303
[18]
VIRAL MODELS OF DEMYELINATION
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
WEINER, LP
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
STOHLMAN, SA
[J].
NEUROLOGY,
1978,
28
(09)
: 111
-
114
[19]
WEINER LP, 1974, PROG MED VIROL, V18, P229
[20]
ISOLATION OF COLD-SENSITIVE MUTANTS OF POLIOVIRUS
WRIGHT, PJ
论文数:
0
引用数:
0
h-index:
0
机构:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
WRIGHT, PJ
COOPER, PD
论文数:
0
引用数:
0
h-index:
0
机构:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
COOPER, PD
[J].
INTERVIROLOGY,
1973,
2
(01)
: 20
-
24
←
1
2
→
共 20 条
[11]
SOMMERS K, 1973, P NAT ACAD SCI US, V70, P2206
[12]
STABILITY OF NEUROTROPIC MOUSE HEPATITIS VIRUS (JHM STRAIN) DURING CHRONIC INFECTION OF NEUROBLASTOMA-CELLS
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
STOHLMAN, SA
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
WEINER, LP
[J].
ARCHIVES OF VIROLOGY,
1978,
57
(01)
: 53
-
61
[13]
RESCUE OF A POSITIVE STRANDED RNA VIRUS FROM ANTIGEN NEGATIVE NEURO-BLASTOMA CELLS
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
STOHLMAN, SA
SAKAGUCHI, AY
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
SAKAGUCHI, AY
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT BIOCHEM,LOS ANGELES,CA 90033
WEINER, LP
[J].
LIFE SCIENCES,
1979,
24
(11)
: 1029
-
1035
[14]
ENHANCED GROWTH OF A MURINE CORONAVIRUS IN TRANSFORMED MOUSE CELLS
STURMAN, LS
论文数:
0
引用数:
0
h-index:
0
STURMAN, LS
TAKEMOTO, KK
论文数:
0
引用数:
0
h-index:
0
TAKEMOTO, KK
[J].
INFECTION AND IMMUNITY,
1972,
6
(04)
: 501
-
&
[15]
TERMEULEN V, 1970, CURR TOP MICROBIOL I, V57, P1
[16]
WALKER DL, 1964, PROG MED VIROL, V6, P111
[17]
PATHOGENESIS OF DEMYELINATION INDUCED BY A MOUSE HEPATITIS VIRUS (JHM VIRUS)
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
JOHNS HOPKINS UNIV, SCH MED,DEPT NEUROL, BALTIMORE, MD 21205 USA
JOHNS HOPKINS UNIV, SCH MED,DEPT NEUROL, BALTIMORE, MD 21205 USA
WEINER, LP
[J].
ARCHIVES OF NEUROLOGY,
1973,
28
(05)
: 298
-
303
[18]
VIRAL MODELS OF DEMYELINATION
WEINER, LP
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
WEINER, LP
STOHLMAN, SA
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
UNIV SO CALIF,SCH MED,DEPT MICROBIOL,LOS ANGELES,CA 90033
STOHLMAN, SA
[J].
NEUROLOGY,
1978,
28
(09)
: 111
-
114
[19]
WEINER LP, 1974, PROG MED VIROL, V18, P229
[20]
ISOLATION OF COLD-SENSITIVE MUTANTS OF POLIOVIRUS
WRIGHT, PJ
论文数:
0
引用数:
0
h-index:
0
机构:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
WRIGHT, PJ
COOPER, PD
论文数:
0
引用数:
0
h-index:
0
机构:
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
AUSTRALIAN NATL UNIV,JOHN CURTIN SCH MED RES,DEPT MICROBIOL,BOX 4,CANBERRA 2600,AUSTRALIA
COOPER, PD
[J].
INTERVIROLOGY,
1973,
2
(01)
: 20
-
24
←
1
2
→