DIFFERENT TYPES OF ALLOSPECIFIC CTL CLONES IDENTIFIED BY THEIR ABILITY TO RECOGNIZE PEPTIDE LOADING-DEFECTIVE TARGET-CELLS

被引:69
作者
AOSAI, F
OHLEN, C
LJUNGGREN, HG
HOGLUND, P
FRANKSSON, L
PLOEGH, H
TOWNSEND, A
KARRE, K
STAUSS, HJ
机构
[1] UNIV LONDON MIDDLESEX HOSP,COURTAULD INST BIOCHEM,IMPERIAL CANC RES FUND,HTIG,91 RIDING HOUSE ST,LONDON W1P 8BT,ENGLAND
[2] UNIV LONDON UNIV COLL,IMPERIAL CANC RES FUND,TUMOUR IMMUNOL UNIT,LONDON WC1E 6BT,ENGLAND
[3] KAROLINSKA INST,DEPT TUMOR BIOL,S-10401 STOCKHOLM 60,SWEDEN
[4] JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND
[5] NETHERLANDS CANC INST,1066 CX AMSTERDAM,NETHERLANDS
关键词
D O I
10.1002/eji.1830211118
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Allospecific immune responses against the MHC of another individual are remarkably strong, due to a high number of responding T cell clones. Although it has been demonstrated that some allospecific cytotoxic T lymphocytes (CTL) recognize peptides presented by allogeneic MHC class I molecules, it has remained unclear whether MHC molecules can be recognized directly. We used the H-2b-derived murine lymphoma mutant RMA-S, which has a defect affecting peptide loading of class I molecules, to test whether recognition by allospecific CTL always requires the presence of peptides. Three types of anti-H-2K(b) CTL clones can be distinguished by their ability to lyse RMA-S target cells. Type A CTL clones efficiently lyse these target cells, the lysis by type B CTL clones is inefficient, and type C clones fail to lyse RMA-S. Up-regulation of the levels of H-2K(b) density improved lysis by type B clones, but did not lead to lysis by type C clones. Some type A and B CTL clones apparently can recognize class I molecules devoid of peptides, while others are likely to recognize peptides which are not affected by the presentation defect of RMA-S. We suggest that type C clones are specific for peptides which are not presented by the mutant cells. The results show that the majority of alloreactive CTL recognize peptide/MHC complexes, while some CTL behave as if they can recognize class I molecules in the absence of MHC-bound peptides.
引用
收藏
页码:2767 / 2774
页数:8
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