ALTERED PLATELET PROTEIN-KINASE-C ACTIVITY IN BIPOLAR AFFECTIVE-DISORDER, MANIC EPISODE

被引：149

作者：

FRIEDMAN, E ^{[1
]}

WANG, HY ^{[1
]}

LEVINSON, D ^{[1
]}

CONNELL, TA ^{[1
]}

SINGH, H ^{[1
]}

机构：

[1] MED COLL PENN,EPPI,DEPT PHARMACOL,PHILADELPHIA,PA 19129

来源：

BIOLOGICAL PSYCHIATRY | 1993年 / 33卷 / 07期

关键词：

PROTEIN KINASE-C; PLATELET; BIPOLAR AFFECTIVE DISORDER; MANIA; LITHIUM; SEROTONIN;

D O I：

10.1016/0006-3223(93)90006-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Protein kinase C (PKC) activity and PKC translocation in response to serotonin were investigated in platelets obtained from bipolar affective disorder subjects before and during lithium treatment. Ratios of platelet membrane-bound to cytosolic PKC activities were elevated in the manic subjects. In addition, serotonin-elicited platelet PKC translocation was found to be enhanced in those subjects. Lithium treatment for up to 2 weeks resulted in a reduction in cytosolic and membrane-associated PKC activities and in an attenuated PKC translocation in response to serotonin. These preliminary results suggest that alteration in platelet PKC is associated with the manic phase of bipolar illness. The results also suggest that lithium treatment reduces the sensitivity of platelets to PKC translocation induced by activation of serotonin-2 receptors.

引用

页码：520 / 525

页数：6

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