CHARACTERIZATION OF A MOLECULE RELATED TO CALCITONIN-GENE-RELATED PEPTIDE (CGRP) IN THE SCALLOP, PECTEN-MAXIMUS

被引：15

作者：

FOUCHEREAUPERON, M

机构：

[1] Laboratoire de Biologie Marine, Collège de France

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 1993年 / 105卷 / 3-4期

关键词：

D O I：

10.1016/0305-0491(93)90109-I

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

1. The presence of calcitonin (CT) and calcitonin gene related peptide (CGRP) was investigated in tissues of the scallop, Pecten maximus. 2. By means of specific radioimmunoassays, CGRP- and CT-like molecules were detected in heart, kidney and hepatopancreas. 3. No inhibition of the CT bound to rat kidney membranes was found either by heart or kidney extracts. 4. Only heart extracts inhibit the CGRP bound to rat liver membranes. 5. All these data suggest that CGRP may represent the ancestral molecule and that CT appears later in evolution.

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收藏

页码：707 / 711

页数：5

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