CALCIUM-CALMODULIN DEPENDENCE OF ACTIN ACCRETION AND LETHALITY IN CULTURED HEP-2 CELLS INFECTED WITH ENTEROPATHOGENIC ESCHERICHIA-COLI

被引：43

作者：

BALDWIN, TJ

LEEDELAUNAY, MB

KNUTTON, S

WILLIAMS, PH

机构：

[1] UNIV LEICESTER, DEPT GENET, LEICESTER LE1 7RH, ENGLAND

[2] UNIV BIRMINGHAM, INST CHILD HLTH, BIRMINGHAM B16 8ET, ENGLAND

来源：

INFECTION AND IMMUNITY | 1993年 / 61卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/IAI.61.2.760-763.1993

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Infection of cultured HEp-2 cells with enteropathogenic Escherichia coli causes substantial actin accretion at points of bacterial contact and cell death. Loss of viability was delayed by chelating intracellular free calcium. Actin accretion was partially inhibited by preventing elevation of free cytosolic calcium and prevented by treatment with a calmodulin inhibitor.

引用

页码：760 / 763

页数：4