USEFULNESS OF SKIN TESTING WITH MYCOBACTERIAL ANTIGENS IN CHILDREN WITH CERVICAL LYMPHADENOPATHY

被引:32
作者
HUEBNER, RE
SCHEIN, MF
CAUTHEN, GM
GEITER, LJ
OBRIEN, RJ
机构
[1] Division of Tuberculosis Elimination, National Center for Prevention Sevices, Centers for Disease Control, Atlanta, GA
关键词
TUBERCULIN; MYCOBACTERIA; SKIN TESTING; CERVICAL LYMPHADENOPATHY;
D O I
10.1097/00006454-199206000-00006
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
One hundred twenty-three children with chronic cervical lymphadenopathy were skin-tested with purified protein derivative (PPD)-B (Mycobacterium intracellulare), PPD-Y (Mycobacterium kansasii), PPD-G (Mycobacterium scrofulaceum) (nontuberculous mycobacterial antigens (NTMags)) and PPD-T (Mycobacterium tuberculosis). Children with culture-confirmed mycobacterial disease had significantly larger reactions to NTMags and were 6 times more likely to have PPD-B responses of greater-than-or-equal-to 10 mm than those with negative microscopy/culture results. Children with acid-fast bacilli present in clinical specimens but with negative culture results were 3 times more likely to have greater-than-or-equal-to 10 mm induration to PPD-B than those with negative microscopy/culture results. In all groups except those with culture-confirmed M. tuberculosis, responses to PPD-T were significantly smaller than those to the NTMags. We conclude that NTMags, particularly PPD-B, may be useful in diagnosing childhood mycobacterial cervical adenopathy; however, their usefulness in distinguishing disease caused by M. tuberculosis from that resulting from other mycobacteria is unknown.
引用
收藏
页码:450 / 456
页数:7
相关论文
共 22 条
[11]   CLINICAL STUDY OF THE CHRONIC LUNG DISEASE DUE TO NONPHOTOCHROMOGENIC ACID-FAST BACILLI [J].
LEWIS, AG ;
LASCHE, EM ;
ARMSTRONG, AL ;
DUNBAR, FP .
ANNALS OF INTERNAL MEDICINE, 1960, 53 (02) :273-285
[12]   CHRONIC LYMPHADENOPATHY DUE TO MYCOBACTERIAL INFECTION - CLINICAL-FEATURES, DIAGNOSIS, HISTOPATHOLOGY, AND MANAGEMENT [J].
MARGILETH, AM ;
CHANDRA, R ;
ALTMAN, RP .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1984, 138 (10) :917-922
[14]  
MARGILETH AM, 1985, AM FAM PHYSICIAN, V31, P166
[15]   DIFFERENTIAL TUBERCULIN TEST FOR MYCOBACTERIAL INFECTION IN CHILDREN [J].
MARKS, J ;
PALFREYMAN, JM ;
YATES, MD ;
SCHAEFER, WB .
TUBERCLE, 1977, 58 (01) :19-23
[16]  
OBRIEN RJ, 1987, AM REV RESPIR DIS, V135, P1007
[17]  
Seibert Florence B., 1941, AMER REV TUBERC, V44, P9
[18]  
TIMPE A, 1954, J LAB CLIN MED, V44, P202
[19]  
WOLINSKY E, 1979, AM REV RESPIR DIS, V119, P107
[20]  
1985, SAS USERS GUIDE STAT