VACCINATION OF MICE AGAINST CANINE-DISTEMPER VIRUS-INDUCED ENCEPHALITIS WITH VACCINIA VIRUS RECOMBINANTS ENCODING MEASLES OR CANINE-DISTEMPER VIRUS-ANTIGENS

被引：31

作者：

WILD, TF

BERNARD, A

SPEHNER, D

VILLEVAL, D

DRILLIEN, R

机构：

[1] FAC MED ALEXIS CARREL,INSERM,CJF 90 10,F-69372 LYON 08,FRANCE

[2] TRANSGENE SA,F-67000 STRASBOURG,FRANCE

[3] UNIV STRASBOURG 1,INSERM,U74,F-67070 STRASBOURG,FRANCE

来源：

VACCINE | 1993年 / 11卷 / 04期

关键词：

CANINE DISTEMPER VIRUS; MEASLES VIRUS; VACCINIA VIRUS RECOMBINANTS;

D O I：

10.1016/0264-410X(93)90285-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Measles and canine distemper are caused by serologically related viruses. Although dogs immunized with measles virus (MV) do not elicit canine distemper virus (CD V) neutralizing antibodies, they are protected against the fatal disease. To investigate the potential role of the MV antigens in protection against CDV, we have immunized mice with vaccinia virus (VV) recombinants expressing the MV haemagglutinin (HA), fusion (F), nucleoprotein (NP) and matrix (M) antigens and challenged them with CDV. A partial protection was observed with the VV recombinants expressing the F, NP and M antigens, but not the HA. In contrast, immunization with a VV recombinant expressing the CDV F protein completely protected mice from CDV.

引用

收藏

页码：438 / 444

页数：7

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