EFFECTS OF D-PENICILLAMINE ON LYMPHOCYTE MODULATION OF SYNOVIAL COLLAGENASE PRODUCTION

被引：8

作者：

DEVORE, DP ^{[1
]}

GRUEBEL, RJ ^{[1
]}

HUTSON, TB ^{[1
]}

TURNER, RH ^{[1
]}

机构：

[1] RICHARD H TURNER MD INC,COLUMBUS,OH 43215

来源：

AGENTS AND ACTIONS | 1979年 / 9卷 / 02期

关键词：

D O I：

10.1007/BF02024730

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

While D-Penicillamine is effective in the treatment of rheumatoid arthritis, its mechanism of action is unknown. In this study, effects of D-Penicillamine on collagenase production by adherent rheumatoid synovial cells were investigated. D-Penicillamine did not directly affect synovial collagenase production. However, lymphocyte-free-supernatant (LFS) recovered from lymphocytes exposed to D-Penicillamine in vivo and in vitro significantly reduced collagenase production by adherent synovial cells. LFS from lymphocytes of normal subjects and from non-D-Penicillamine treated rheumatoid patients stimulated collagenase production. These investigations indicate that D-Penicillamine indirectly affects collagenase production by cultured synovial cells and suggests beneficial effects on controlling the primary disease process. © 1979 Birkhäuser-Verlag.

引用

页码：172 / 176

页数：5

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