INHIBITION OF POLYAMINE BIOSYNTHESIS BY ALPHA-DIFLUOROMETHYL ORNITHINE POTENTIATES THE CYTO-TOXIC EFFECTS OF ARABINOSYL CYTOSINE IN HELA-CELLS

被引：68

作者：

SUNKARA, PS ^{[1
]}

FOWLER, SK ^{[1
]}

NISHIOKA, K ^{[1
]}

RAO, PN ^{[1
]}

机构：

[1] UNIV TEXAS,MD ANDERSON HOSP & TUMOR INST,SYST CANC CTR,DEPT SURG,HOUSTON,TX 77030

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1980年 / 95卷 / 01期

关键词：

D O I：

10.1016/0006-291X(80)90755-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：423 / 430

页数：8

共 21 条

[1] POSSIBLE INVOLVEMENT OF POLYAMINES IN INITIATION OF DNA-SYNTHESIS BY HUMAN WI-38 AND MOUSE BALB-3T3 CELLS [J].

BOYNTON, AL ;

WHITFIELD, JF ;

ISAACS, RJ .

JOURNAL OF CELLULAR PHYSIOLOGY, 1976, 89 (03) :481-488

[2] INCREASED CELLULAR LEVELS OF SPERMIDINE OR SPERMINE ARE REQUIRED FOR OPTIMAL DNA-SYNTHESIS IN LYMPHOCYTES ACTIVATED BY CONCANAVALIN A [J].

FILLINGAME, RH ;

JORSTAD, CM ;

MORRIS, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :4042-4045

[3] MAMMALIAN CELL FUSION - INDUCTION OF PREMATURE CHROMOSOME CONDENSATION IN INTERPHASE NUCLEI [J].

JOHNSON, RT ;

RAO, PN .

NATURE, 1970, 226 (5247) :717-&

[4] DNA-SYNTHESIS IN HELA-CELLS AND ISOLATED-NUCLEI AFTER TREATMENT WITH AN INHIBITOR OF SPERMIDINE SYNTHESIS, METHYL GLYOXAL BIS(GUANYLHYDRAZONE) [J].

KROKAN, H ;

ERIKSEN, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1977, 72 (03) :501-508

[5] ANTI-PROLIFERATIVE PROPERTIES OF DL-ALPHA-DIFLUOROMETHYL ORNITHINE IN CULTURED-CELLS - CONSEQUENCE OF IRREVERSIBLE INHIBITION OF ORNITHINE DECARBOXYLASE [J].

MAMONT, PS ;

DUCHESNE, MC ;

GROVE, J ;

BEY, P .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1978, 81 (01) :58-66

[6] ALPHA-METHYL ORNITHINE, A POTENT COMPETITIVE INHIBITOR OF ORNITHINE DECARBOXYLASE, BLOCKS PROLIFERATION OF RAT HEPATOMA-CELLS IN CULTURE [J].

MAMONT, PS ;

BOHLEN, P ;

MCCANN, PP ;

BEY, P ;

SCHUBER, F ;

TARDIF, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (05) :1626-1630

[7]

MARTON LJ, 1975, CLIN CHEM, V21, P1721

[8] CATALYTIC IRREVERSIBLE INHIBITION OF MAMMALIAN ORNITHINE DECARBOXYLASE (E C 4 1 1 17) BY SUBSTRATE AND PRODUCT ANALOGS [J].

METCALF, BW ;

BEY, P ;

DANZIN, C ;

JUNG, MJ ;

CASARA, P ;

VEVERT, JP .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (08) :2551-2553

[9]

MORRIS DR, 1977, CANCER RES, V37, P3169

[10] INHIBITION OF EMT6 TUMOR-GROWTH BY INTERFERENCE WITH POLYAMINE BIOSYNTHESIS - EFFECTS OF ALPHA-DIFLUOROMETHYLORNITHINE, AN IRREVERSIBLE INHIBITOR OF ORNITHINE DECARBOXYLASE [J].

PRAKASH, NJ ;

SCHECHTER, PJ ;

MAMONT, PS ;

GROVE, J ;

KOCHWESER, J ;

SJOERDSMA, A .

LIFE SCIENCES, 1980, 26 (03) :181-194

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