THE CANCER-INITIATING POTENTIAL OF THE FUMONISIN-B MYCOTOXINS

被引：140

作者：

GELDERBLOM, WCA ^{[1
]}

SEMPLE, E ^{[1
]}

MARASAS, WFO ^{[1
]}

FARBER, E ^{[1
]}

机构：

[1] UNIV TORONTO,DEPT PATHOL,TORONTO M5S 1A8,ONTARIO,CANADA

来源：

CARCINOGENESIS | 1992年 / 13卷 / 03期

关键词：

D O I：

10.1093/carcin/13.3.433

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The cancer-initiating potential of the fumonisin B (FB) mycotoxins produced by Fusarium moniliforme was screened in rat liver for their ability to induce rare hepatocytes with an acquired resistance to the mitoinhibitory effect of 2-acetylaminofluorene (2-AAF). Two different initiating protocols were used: a feeding regimen during which FB1 was fed at a dietary level of 0.1% for 26 days, and another where single or multiple doses of FB1 and FB2 (varying from 200 to 50 mg/kg) were administered (by gavage) to hepatectomized rats. In both cases promotion was effected by a 2-acetylaminofluorene/carbontetrachloride treatment. Cancer initiation was only obtained after the prolonged feeding regimen, indicating that the fumonisins are poor cancer initiators. FB1 and FB2 also lack genotoxic effects in the in vivo and in vitro DNA repair assays in primary hepatocytes. Although FB1 primarily affects the liver, it is not very cytotoxic to primary hepatocytes when compared to aflatoxin B1.

引用

页码：433 / 437

页数：5